Role of eosinophil extracellular traps in the pathogenesis of chronic airway diseases / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 241-244, 2022.
Article
in Zh
| WPRIM
| ID: wpr-934038
Responsible library:
WPRO
ABSTRACT
Eosinophil extracellular traps (EETs), an important pathway of eosinophil to exert its effects, are composed of DNA fibers, histone and eosinophil granule proteins. Recently, many researches have shown that EETs play an important role in the genesis and development of respiratory diseases including asthma, allergic bronchopulmonary aspergillosis and chronic obstructive pulmonary disease. EETs can directly damage airway epithelial cells, promote airway inflammation and airway hypersecretion, increase the stickiness of secretions and induce the generation of autoantibody, helping eosinophils and their products participate in a cascade of events leading to inflammation and disease. Researches on EETs can also be helpful in investigating new targets for the treatment of chronic airway diseases.
Full text:
1
Database:
WPRIM
Type of study:
Etiology_studies
Language:
Zh
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2022
Document type:
Article